In Spy Fox: Dry Cereal, Spy Fox is charged with stopping the evil William the Kid, whose dastardly plan is to replace cow milk with goat milk on breakfast tables and lunch trays all over the world. Spy Fox, suave and sophisticated in his tux, is sent to the Greek isle Acidophilus to foil Kid's scheme. Assisting him are the ever-reliable Monkey Penny and Professor Quack.
Kids move Fox through a series of screens where they can use the Wii Remote to click on various objects, pick up items they will need later, and interact with characters such as Russian Blue and Hong Kong Doodle. A series of puzzles must be solved, leading the player deeper and deeper into Kid's lair before the final thrilling chase and capture of the fiendish villain.